Table 5.
GSEA analyzed significantly enriched KEGG pathways in high-risk and low-risk groups.
| Name | Size | ES | NES | NOM p-val | FDR q-val | FWER p-val |
|---|---|---|---|---|---|---|
| KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 243 | -0.609 | -2.002 | 0.0001 | 0.055 | 0.037 |
| KEGG_LEISHMANIA_INFECTION | 64 | -0.709 | -1.985 | 0.0001 | 0.039 | 0.052 |
| KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | 68 | -0.726 | -1.969 | 0.0001 | 0.035 | 0.064 |
| KEGG_HEMATOPOIETIC_CELL_LINEAGE | 84 | -0.708 | -1.967 | 0.0001 | 0.026 | 0.064 |
| KEGG_CELL_ADHESION_MOLECULES_CAMS | 122 | -0.623 | -1.961 | 0.002 | 0.023 | 0.07 |
| KEGG_VIRAL_MYOCARDITIS | 67 | -0.636 | -1.933 | 0.0001 | 0.028 | 0.1 |
| KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION | 108 | -0.551 | -1.920 | 0.002 | 0.029 | 0.115 |
| KEGG_AUTOIMMUNE_THYROID_DISEASE | 49 | -0.710 | -1.817 | 0.002 | 0.075 | 0.259 |
| KEGG_CHEMOKINE_SIGNALING_PATHWAY | 178 | -0.491 | -1.799 | 0.020 | 0.080 | 0.3 |
| KEGG_ASTHMA | 27 | -0.790 | -1.795 | 0.0001 | 0.075 | 0.306 |
| KEGG_TYPE_I_DIABETES_MELLITUS | 40 | -0.747 | -1.791 | 0.008 | 0.070 | 0.316 |
| KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES | 14 | -0.681 | -1.732 | 0.008 | 0.107 | 0.454 |
| KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION | 45 | -0.727 | -1.720 | 0.009 | 0.109 | 0.476 |
| KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY | 127 | -0.510 | -1.710 | 0.018 | 0.112 | 0.505 |
| KEGG_ALLOGRAFT_REJECTION | 34 | -0.807 | -1.709 | 0.006 | 0.105 | 0.508 |
| KEGG_ECM_RECEPTOR_INTERACTION | 82 | -0.592 | -1.708 | 0.023 | 0.100 | 0.511 |
| KEGG_JAK_STAT_SIGNALING_PATHWAY | 147 | -0.468 | -1.701 | 0.014 | 0.100 | 0.525 |
| KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION | 78 | -0.581 | -1.692 | 0.033 | 0.102 | 0.546 |
| KEGG_LYSOSOME | 115 | -0.483 | -1.683 | 0.024 | 0.103 | 0.562 |
| KEGG_GRAFT_VERSUS_HOST_DISEASE | 36 | -0.780 | -1.669 | 0.016 | 0.109 | 0.595 |
| KEGG_FOCAL_ADHESION | 189 | -0.484 | -1.664 | 0.031 | 0.109 | 0.607 |
| KEGG_PRION_DISEASES | 35 | -0.487 | -1.662 | 0.006 | 0.106 | 0.613 |
| KEGG_RENIN_ANGIOTENSIN_SYSTEM | 16 | -0.603 | -1.655 | 0.028 | 0.107 | 0.624 |
| KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY | 54 | -0.489 | -1.608 | 0.041 | 0.142 | 0.722 |
| KEGG_HISTIDINE_METABOLISM | 26 | -0.484 | -1.592 | 0.046 | 0.154 | 0.757 |
| KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM | 82 | -0.445 | -1.583 | 0.037 | 0.157 | 0.776 |
| KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 99 | -0.441 | -1.574 | 0.048 | 0.160 | 0.787 |
| KEGG_OTHER_GLYCAN_DEGRADATION | 15 | -0.587 | -1.532 | 0.060 | 0.201 | 0.852 |
| KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION | 47 | -0.415 | -1.515 | 0.026 | 0.216 | 0.874 |
| KEGG_BASAL_TRANSCRIPTION_FACTORS | 34 | 0.584 | 1.895 | 0.004 | 0.141 | 0.131 |
| KEGG_NUCLEOTIDE_EXCISION_REPAIR | 44 | 0.607 | 1.855 | 0.004 | 0.124 | 0.2 |
| KEGG_CELL_CYCLE | 112 | 0.531 | 1.841 | 0.004 | 0.100 | 0.231 |
| KEGG_HOMOLOGOUS_RECOMBINATION | 24 | 0.700 | 1.831 | 0.004 | 0.082 | 0.246 |
| KEGG_SPLICEOSOME | 90 | 0.605 | 1.811 | 0.004 | 0.081 | 0.283 |
| KEGG_DNA_REPLICATION | 32 | 0.732 | 1.767 | 0.004 | 0.106 | 0.392 |
| KEGG_MISMATCH_REPAIR | 23 | 0.674 | 1.718 | 0.016 | 0.141 | 0.503 |
| KEGG_BASE_EXCISION_REPAIR | 33 | 0.609 | 1.680 | 0.024 | 0.165 | 0.59 |
| KEGG_RNA_DEGRADATION | 47 | 0.530 | 1.676 | 0.012 | 0.152 | 0.6 |
| KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS | 22 | 0.570 | 1.638 | 0.024 | 0.179 | 0.675 |
| KEGG_RNA_POLYMERASE | 28 | 0.556 | 1.622 | 0.033 | 0.181 | 0.711 |