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High-fat diet increases plasma TNF and CCL2 during the acute phase of experimental T. cruzi infection. TNF (a), CCL2 (b), and IL-10 (c) were measured by immunoassays in the plasma of C57BL/6 mice at 30 days of T. cruzi infection and after receiving normolipidic or high-fat diets. White bars: noninfected animals with and without simvastatin treatment; black bars: T. cruzi-infected mice with and without simvastatin treatment. Data are mean ± standard error of the mean (SEM).
