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Tumor inhibition in vivo. (A) Tumor volume and (B) tumor inhibition rate of K7 osteosarcoma-allografted mouse after treatment with PBS, free DOX, NP/DOX, or CaNP/DOX. Data are presented as mean ± SD (n = 6). (C) Photos and (D) tumor weights of excised tumors after treatment with PBS, free DOX, NP/DOX, or CaNP/DOX at 15 days post-treatment. Data are presented as mean ± SD (n = 4; *P < 0.05, **P < 0.01, ***P < 0.001).
