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. 2020 Jun 12;5(3):721–731. doi: 10.1016/j.bioactmat.2020.04.010

Fig. 5.

Fig. 5

In vivo antitumor effect and anti-bone destruction effect against 143B osteosarcoma-bearing BALB/c mouse model. (A) Tumor region volumes and (B) photos of tibial primary osteosarcoma tumors. (C) 3D reconstructed image of tibia performed using micro-CT of 143B osteosarcoma-bearing BALB/c mouse after treatment with PBS, free DOX, NP/DOX, or CaNP/DOX. (D) Bone volume/total volume (BV/TV) and (E) trabecular number (Tb. N) in the regions of interest (ROI) of mouse. Data are presented as mean ± SD (n = 4; *P < 0.05, **P < 0.01, ***P < 0.001).