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. 2020 Jun 12;5(3):721–731. doi: 10.1016/j.bioactmat.2020.04.010

Fig. 6.

Fig. 6

Inhibition of tumor growth toward 143B osteosarcoma-bearing BALB/c mouse model. (A) Histopathological (H&E) analysis of tumor from 143B orthotopic osteosarcoma mouse after treatment with PBS, free DOX, NP/DOX, or CaNP/DOX. (B, C) Immunofluorometric analysis (Ki-67, p53) of tumor sections from 143B orthotopic osteosarcoma mouse after treatment with PBS, free DOX, NP/DOX, or CaNP/DOX. (D, E) Relative Ki-67 and p53 positive areas of tumor sections. Data are presented as mean ± SD (n = 4; *P < 0.05, **P < 0.01, ***P < 0.001).