FIG 1.

Analysis of LMP1-interacting proteins enriched in vesicle-mediated transport. All unique LMP1-interacting proteins identified were analyzed using Reactome V 69. (A) Genome-wide overview of the pathway analysis. The center of the circular “bursts” is the root of one top-level pathway, and the color-code denotes overrepresentation of that pathway in the input data set. Light gray signifies pathways that are not significantly overrepresented. (B) Representation of different downstream pathways associated with the “vesicle-mediated transport” node. (C) LMP1-interacting proteins associated with the ESCRT pathway. (D) Model of different ESCRT components involved in extracellular vesicle formation and secretion. ESCRT components with * in the model were identified as LMP1-interacting proteins. ER, endoplasmic reticulum; vmiRNA, viral microRNA; ILV, intraluminal vesicles; GEFs, guanine nucleotide exchange factors; COPI, coat protein I.