FIG 6.

Acute DINO expression increases susceptibility to chemotherapy agents. Inducible DINO vector-transduced, HPV16-positive CaSki cervical cancer cells were treated with the indicated concentrations of cisplatin (A), doxorubicin (B), mitomycin C (C), and 5-fluorouracil (D). Cell viability was assessed at 72 h posttreatment. Graphs represent means ± SEM from single representative experiments, each performed in triplicate. ***, P < 0.001; *, P < 0.05 (Student’s t test). Similar results were obtained in three independent experiments.