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. 2020 Jun 16;20:247. doi: 10.1186/s12935-020-01310-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Circ_0000284 negatively regulated the expression of miR-377-3p. a Circular RNA Interactome was applied for the bioinformatics analysis of circ_0000284 and miR-377-3p. b, c The binding between circ_0000284 and miR-377-3p was testified by dual-luciferase reporter assay (b) and RIP assay (c). d The overexpression efficiency of circ_0000284 in A549 and H82 cells was assessed via qRT-PCR. e The qRT-PCR was administrated to estimate the effects of circ_0000284 up-regulation or down-regulation on the expression of miR-377-3p. All experiments were independently performed three times with N value = 3. *P < 0.05