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. 2020 Jun 16;39:113. doi: 10.1186/s13046-020-01618-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Co-overexpression of AHR, RhoA and ROCK1 predicted poor prognosis and targeting RhoA/ROCK1 pathway can reverse EMT. a. Survival analysis of single AHR, RhoA or ROCK1 expression levels or combined. Co-overexpression of above three proteins predicted poor prognosis of ESCC. b. Knockdown of ROCK1 with specific siRNAs could reverse EMT process as well as downregulate expression of MMPs. c. Blockade of RhoA/ROCK1 pathway with inhibitor Fasudil could actually reverse EMT of ESCC. * P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance