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. 2020 Jun 16;20:562. doi: 10.1186/s12885-020-07046-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Serum levels of bone turnover markers and their abilities to diagnose bone metastasis in stage IV lung cancer patients. a, b Box plot distribution of the serum levels of the bone turnover markers tPINP and β-CTx from three groups, including the bone metastasis group (n = 127), the non-bone metastasis group (n = 78), and the healthy control group (n = 106). For details of the box plots, see the legend of Fig. 1. c ROC analysis of the ability of the serum bone turnover markers tP1NP and β-CTx to diagnose bone metastasis. d ROC analysis of the diagnostic efficiency of the combination of tP1NP and β-CTx