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. 2020 Jun 16;20:562. doi: 10.1186/s12885-020-07046-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Evaluation of the attributable risk and diagnostic efficiency of these parameters for bone metastasis in 205 patients with stage IV primary lung cancer. a Multivariate logistic regression analysis to evaluate the attributable risk of these parameters for bone metastasis. OR values were presented by log2 transformation. OR: odds ratio, CI: confidence interval. * P < 0.05 was considered statistically significant. b ROC analysis to assess the diagnostic efficiency for bone metastasis of different combinations of the four independent diagnostic risk factors, including BME cytokines (OPG and PTHrP) and bone turnover markers (tP1NP and β-CTx)