Table 1.
Body mass index and lung function of study populations included in the genotype-outcome association analyses
| MR step | Study | N | Age (years), median (IQR) | BMI (kg/m2), median (IQR) | FEV1 (L), median (IQR) | FVC (L), median (IQR) | FEV1/FVC (%),median (IQR) |
|---|---|---|---|---|---|---|---|
| 1st | ECRHS | 470 | 55 (49–60) | 26.0 (23.3–29.3) | 2.9 (2.4–3.5) | 3.8 (3.2–4.6) | 76 (72–80) |
| NFBC1966 | 681 | 46 (46–47) | 25.8 (23.3–29.1) | 3.4 (2.9–4.0) | 4.4 (3.8–5.2) | 77 (74–81) | |
| SAPALDIA | 906 | 58 (50–68) | 25.9 (23.3–29.3) | 2.9 (2.4–3.5) | 4.0 (3.3–4.8) | 74 (69–78) | |
| 2nd | ECRHS | 773 | 54 (48–60) | 26.3 (23.8–29.8) | 2.9 (2.5–3.5) | 3.9 (3.3–4.7) | 76 (72–80) |
| NFBC1966 | 4501 | 47 (46–47) | 26.1 (23.5–29.4) | 3.3 (2.9–3.9) | 4.3 (3.7–5.1) | 78 (74–82) | |
| SAPALDIA | 2303 | 60 (50–67) | 25.7 (23.1–28.6) | 3.0 (2.5–3.6) | 4.1 (3.4–4.9) | 74 (69–78) | |
| UK Biobank | 275,861 | 58 (50–63) | 26.6 (24.1–29.7) | 2.7 (2.3–3.3) | 3.6 (3.0–4.3) | 77 (73–80) |
MR Mendelian randomisation. IQR Interquartile range. BMI Body mass index. FEV1 Forced expiratory volume in one second. FVC Forced vital capacity