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. 2020 Jun 16;20:171. doi: 10.1186/s12890-020-01212-9

Table 2.

Step 1: IVW fixed-effect MR estimates of the causal effect of BMI on CpG methylation

ECRHS + NFBC (n = 1151) SAPALDIA (n = 906)
CpG Gene Chromosomal position MR estimate (SE)a P I2b MR estimate (SE)a P I2b
cg09046979 SBK1 16:28333134 −0.021 (0.010) 0.03 41% 0.007 (0.015) 0.6 39%
cg12580248 NPIPB11 16:29412940 0.022 (0.012) 0.08 43%

aChange in methylation (unit is %) per one-unit increase in BMI (kg/m2); MR Mendelian randomisation; SE Standard error. bBetween-instrument heterogeneity