Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 16;13:77. doi: 10.1186/s13045-020-00906-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — IGF-1R inhibitors exert cytotoxic effects on DLBCL cells. a LY1 and LY8 cells were treated with IGF-1R inhibitor AG1024 or PPP at the indicated concentrations for 24 h, and cell proliferation was determined by CCK-8 assay (mean ± SD, n = 6). b, c After treatment with an IGF-1R inhibitor (AG1024 or PPP) at the indicated concentrations for 24 h, cellular apoptosis was detected by flow cytometry. Representative results are shown. The results of the quantitative analysis are shown as the mean ± SD from at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001. d. Western blot analysis of DLBCL cell lines, treated with a single dose of 15 μM AG1024 for 24 h, was performed to determine the expression of the indicated proteins. e Scatter plots show the positive correlation between YAP and IGF1-R mRNA expression in the TCGA cohort