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. 2020 Jun 16;18:92. doi: 10.1186/s12951-020-00649-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — In vitro drug release and therapeutic efficacy of 4T1 cells treated with different formulations. a Dox release from DPLGA NPs or DPLGA@[RAW-4T1] NPs at pH 4.7, 5.5, and 7.4. Cell viabilities of 4T1 cells incubated with Dox, DPLGA NPs, DPLGA@4T1 NPs, DPLGA@RAW NPs, and DPLGA@[RAW-4T1] NPs for 24 (b) and 48 h (c). d Analysis of apoptosis in 4T1 cells incubated with different groups for 48 h, followed by detection using the apoptosis kit of Annexin V-APC/PI by flow cytometry. e Invasion assay of cells treated with free Dox, DPLGA NPs, DPLGA@4T1 NPs, DPLGA@RAW NPs, and DPLGA@[RAW-4T1] NPs. Scale bar = 200 μm. f Scratch assay of cells treated with free Dox, DPLGA NPs, DPLGA@4T1 NPs, DPLGA@RAW NPs, and DPLGA@[RAW-4T1] NPs revealed wound closure. Scale bar = 200 μm. (mean ± SD, n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001