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. Author manuscript; available in PMC: 2020 Nov 6.
Published in final edited form as: Nature. 2020 May 6;582(7810):124–128. doi: 10.1038/s41586-020-2248-2

Figure 3. The Rec114 boost is intrinsic to short chromosomes.

Figure 3.

a, Targeted translocation between chr1 and chr4 (to scale).

b, Chr1-derived sequences retain high-level Rec114 binding when in a large-chromosome context. Per-chromosome Rec114 ChIP densities normalized to chr15 are shown at 2 and 6 h.

c, Rec114 profiles for wild-type and translocated chromosomes. ChIP-seq data were normalized relative to chr15 (dashed line) and smoothed with a 10-kb sliding window.

d, e, Selective pressure has maintained the short chromosome boost on chr6. Shown are a to-scale schematic of syntenic regions on different-sized chromosomes in S. cerevisiae (Sc) and S. mikatae (Sm) (d) and per-chromosome Rec114 ChIP densities (e).