Table 4.
List of SNPs with p values<1.00E-06 in the family-based genome-wide QTL analysis
| rs_number | Chr | Position | Gene | Region | Minor allele | MAF | GWAS | Genome-wide QTL analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case-control p value | Family-based p value | Case-control inattention p value | Case-control hyperactivity-impulsivityp value | Family-based inattention p value | Family-based hyperactivity-impulsivity p value | |||||||
| rs7684645 | 4 | 165796146 | APELA | Upstream, | A | 0.387 | 6.51E-01 | 1.34E-03 | 4.31E-01 | 7.83E-01 | 1.29E-08 | 1.50E-04 |
| rs12538843 | 7 | 39600097 | POU6F2, YAE1D1 | Intron, downstream, upstream | A | 0.287 | 1.85E-01 | 2.70E-03 | 3.99E-01 | 2.67E-01 | 2.37E-08 | 1.54E-02 |
| rs11074258 | 15 | 94770799 | MCTP2 | Upstream | C | 0.170 | 6.57E-02 | 1.57E-03 | 4.79E-02 | 7.24E-02 | 3.67E-08 | 2.39E-03 |
| rs34396552 | 18 | 12286113 | CIDEA | Downstream | G | 0.359 | 2.93E-01 | 2.70E-03 | 4.25E-01 | 7.69E-02 | 4.76E-08 | 1.41E-03 |
| rs35493881 | 18 | 68153563 | GTSCR1 | Upstream | - | 0.359 | 1.33E-02 | 3.89E-03 | 4.54E-02 | 2.32E-01 | 7.79E-08 | 7.73E-03 |
| rs1239704 | 13 | 51152611 | DLEU1, DLEU7 | Intron, downstream | G | 0.324 | 2.52E-01 | 4.51E-03 | 5.30E-01 | 7.91E-02 | 8.03E-08 | 1.74E-02 |
| rs11119570 | 1 | 206968235 | IL19, IL10 | Upstream | A | 0.396 | 1.98E-01 | 4.51E-03 | 2.67E-01 | 5.66E-01 | 1.43E-07 | 4.76E-04 |
| rs6015071 | 20 | 56314639 | PMEPA1, MIR4532 | Upstream | A | 0.274 | 6.38E-01 | 3.48E-02 | 7.98E-01 | 4.87E-01 | 1.56E-07 | 2.94E-02 |
| rs3116816 | 6 | 29149442 | OR2J2, OR14J1 | Exon, downstream, upstream | A | 0.398 | 1.38E-01 | 2.70E-03 | 9.09E-01 | 3.92E-01 | 1.72E-07 | 3.44E-03 |
| rs6954881 | 7 | 56369816 | NUPR1L | Downstream, upstream | G | 0.472 | 2.42E-01 | 2.28E-03 | 1.02E-01 | 5.39E-01 | 1.82E-07 | 2.80E-03 |
| rs1239682 | 13 | 51165494 | DLEU1, DLEU7 | Intron, downstream | C | 0.333 | 3.00E-01 | 7.53E-03 | 3.45E-01 | 8.47E-01 | 2.59E-07 | 1.36E-02 |
| rs6073330 | 20 | 42737494 | JPH2, TOX2 | Downstream | A | 0.481 | 3.57E-03 | 4.68E-03 | 1.45E-02 | 9.42E-02 | 2.69E-07 | 3.23E-02 |
| rs6796 | 7 | 6502367 | KDELR2, DAGLB | UTR-3, intron, exon | C | 0.491 | 8.41E-02 | 2.70E-03 | 7.82E-01 | 4.34E-01 | 3.16E-07 | 3.33E-02 |
| rs74120710 | 10 | 12937634 | CCDC3, CAMK1D | Downstream | T | 0.157 | 5.46E-02 | 8.15E-03 | 3.38E-01 | 5.12E-01 | 3.23E-07 | 3.91E-03 |
| rs62214554 | 20 | 52807262 | CYP24A1, PFDN4 | Upstream | G | 0.250 | 3.06E-01 | 8.15E-03 | 5.62E-01 | 2.43E-01 | 3.23E-07 | 1.81E-02 |
| rs10800919 | 1 | 203336808 | PRELP, FMOD | Upstream, downstream | C | 0.371 | 2.74E-01 | 1.24E-02 | 2.14E-01 | 2.55E-01 | 4.25E-07 | 4.76E-03 |
| rs1523609 | 7 | 6535517 | GRID2IP, KDELR2 | Downstream, upstream | G | 0.482 | 3.34E-01 | 4.68E-03 | 8.20E-01 | 6.31E-01 | 4.68E-07 | 3.95E-02 |
| rs2817619 | 1 | 11603063 | PTCHD2 | Downstream | T | 0.442 | 1.04E-01 | 2.70E-03 | 3.82E-02 | 8.80E-01 | 5.69E-07 | 4.69E-04 |
| rs16823921 | 2 | 145376116 | TEX41 | Upstream | G | 0.333 | 3.07E-01 | 1.5 7E-03 | 8.32E-01 | 3.56E-01 | 6.12E-07 | 6.81E-05 |
| rs10868138 | 9 | 86917301 | SLC28A3 | Missense, exon | C | 0.093 | 2.47E-01 | 1.43E-02 | 3.83E-01 | 1.23E-01 | 7.29E-07 | 2.60E-03 |
| rs9316596 | 13 | 22469240 | LINC00424, LINC00540 | Upstream, downstream | A | 0.343 | 8.41E-02 | 1.26E-02 | 2.29E-01 | 3.93E-01 | 7.95E-07 | 3.78E-02 |
| rs6699651 | 1 | 7652387 | CAMTA1 | Intron | T | 0.106 | - | 8.15E-03 | - | - | 8.34E-07 | 1.33E-04 |
| rs4945333 | 11 | 78920819 | TENM4 | Intron | G | 0.245 | 5.57E-02 | 6.66E-03 | 4.98E-01 | 5.83E-01 | 9.03E-07 | 4.52E-02 |
| rs214220 | 1 | 48622182 | SKINTL, SLC5A9 | Intron, upstream | C | 0.500 | 1.35E-01 | 7.53E-03 | 3.85E-02 | 8.37E-01 | 9.63E-07 | 1.42E-02 |
| rs9464011 | 6 | 53866266 | MLIP | Intron | C | 0.102 | 2.92E-01 | 8.15E-03 | 6.87E-01 | 8.87E-01 | 3.05E-04 | 7.38E-07 |
APELA: apelin receptor early endogenous ligand, CAMK1D: calcium/calmodulin-dependent protein kinase ID, CAMTA1: calmodulin binding transcription activator 1, CCDC3: coiled-coil domain containing 3, Chr: chromosome, CIDEA: cell death-inducing DFFA-like effector A, CYP24A1: cytochrome P450, family 24, subfamily A, polypeptide 1, DAGLB: diacylglycerol lipase, beta, DLEU1: deleted in lymphocytic leukemia 1, DLEU7: deleted in lymphocytic leukemia, 7, FMOD: fibromodulin, GRID2IP: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, GTSCR1: Gilles de la Tourette syndrome chromosome region, candidate 1, GWAS: genome-wide association study, IL10: interleukin 10, IL19: interleukin 19, JPH2: junctophilin 2, KDELR2: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, LINC00424: long intergenic non-protein coding RNA 424, LINC00540: long intergenic non-protein coding RNA 540, MAF: minor allele frequency, MCTP2: multiple C2 domains, transmembrane 2, MIR4532: microRNA 4532, MLIP: muscular LMNA-interacting protein, NUPR1L: nuclear protein, transcriptional regulator, 1-like, OR14J1: olfactory receptor, family 14, subfamily J, member 1, OR2J2: olfactory receptor, family 2, subfamily J, member 2, PFDN4: prefoldin subunit 4, PMEPA1: prostate transmembrane protein, androgen induced 1, POU6F2: POU class 6 homeobox 2, PRELP: proline/argininerich end leucine-rich repeat protein, PTCHD2: patched domain containing 2, QTL: quantitative trait locus, SKINTL: skint-like, pseudogene, SLC28A3: solute carrier family 28, member 3, SLC5A9: solute carrier family 5, member 9, SNP: single nucleotide polymorphism, TENM4: teneurin transmembrane protein 4, TEX41: testis expressed 41, TOX2: TOX high mobility group box family member 2, YAE1D1: Yae1 domain containing 1.