Figure 1.

Partial MHC II Contructs, DRmQ and DRhQ. DR refers to one of the three human leucocyte antigen (HLA) isotypes along with DP and DQ. The Q refers to a glutamine for lysine amino acid substitution at residue 18 of the DRα1 domain in both constructs. The “h” and “m” refer to the origin of the antigenic MOG‐35‐55 peptide: “h” from human MOG and “m” from mouse origin. The C terminus of the antigenic peptide (in magenta) is covalently linked to the N‐terminus of the DRα1 domain through a flexible peptide linker (black). The human MOG peptide has a proline (P) at position 42, whereas the mouse peptide has a serine (S) at the same position. Structurally, in the DRhQ molecule, the antigenic peptide is bent due mostly to 2 adjoining proline residues. This might explain the difference in activity of the two constructs