Table 2e.
Gentamicin | n | Study type | Absorption | VD (L/kg) | Metabolite CL (mL/kg/hour) | CL (mL/kg/hour) | t1/2 (hour) |
Bijleveld et al49 | 47 | Prospective | / | 0.897 | / | 60 (day 2) 77.4 (29%↑ day 5) |
/ |
Liu et al46 | 55 | Prospective | / | / | / | / | / |
Frymoyer et al50 | 29 | Retrospective | / | 0.47 | / | 36.0 | / |
Ting et al47 | 46 | Retrospective | / | NT=0.45 HT=0.41 |
/ | NT=51.0 TH=33.0 ↓35.3%=↓11.7%/ºC |
NT=7.0 HT=9.6 |
Mark et al48 | 23 | Retrospective | / | / | / | NT=50.0 HT=40.0 ↓25%=↓8.3%/ºC |
NT=6.6 HT=9.2 40%↑ |
Frymoyer et al51 | 52 | Retrospective | / | / | / | 17.0 | / |
Cies et al77 | 12 | Prospective | / | 0.87 | / | 132.0 | / |
Martínková et al78 | 35 | Prospective | / | 0.40 | / | 46.0 | / |
Other antibiotics | |||||||
Cies et al24 (Ampicilline) | 13 | Prospective | / | 0.52 | / | 25.8 | / |
Bijleveld et al53 (Amoxicillin) | 125 | Prospective | / | 0.34 (VC) | / | PNA 0–4=90.0 PNA 5=14.0 55%↑ |
/ |
Bijleveld et al52 (Benzylpenicillin) | 41 | Prospective | / | 0.62 (VC) | / | PNA 0–4=160.0 PNA 5=250.0 56%↑ |
/ |
Cristea et al54 (Amikacin) | 56 | Retrospective | / | 0.832 | / | 49.5 ↓40.6%=↓13.5%/ºC |
/ |