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. 2020 Nov 26;4(1):e000685. doi: 10.1136/bmjpo-2020-000685

Table 2e.

Antibiotics

Gentamicin n Study type Absorption VD (L/kg) Metabolite CL (mL/kg/hour) CL (mL/kg/hour) t1/2 (hour)
Bijleveld et al49 47 Prospective / 0.897 / 60 (day 2)
77.4 (29%↑ day 5)
/
Liu et al46 55 Prospective / / / / /
Frymoyer et al50 29 Retrospective / 0.47 / 36.0 /
Ting et al47 46 Retrospective / NT=0.45
HT=0.41
/ NT=51.0
TH=33.0
↓35.3%=↓11.7%/ºC
NT=7.0
HT=9.6
Mark et al48 23 Retrospective / / / NT=50.0
HT=40.0
↓25%=↓8.3%/ºC
NT=6.6
HT=9.2
40%↑
Frymoyer et al51 52 Retrospective / / / 17.0 /
Cies et al77 12 Prospective / 0.87 / 132.0 /
Martínková et al78 35 Prospective / 0.40 / 46.0 /
Other antibiotics
Cies et al24 (Ampicilline) 13 Prospective / 0.52 / 25.8 /
Bijleveld et al53 (Amoxicillin) 125 Prospective / 0.34 (VC) / PNA 0–4=90.0
PNA 5=14.0
55%↑
/
Bijleveld et al52 (Benzylpenicillin) 41 Prospective / 0.62 (VC) / PNA 0–4=160.0
PNA 5=250.0
56%↑
/
Cristea et al54 (Amikacin) 56 Retrospective / 0.832 / 49.5
↓40.6%=↓13.5%/ºC
/