Table 3.

Dosing recommendations of drugs used in newborns with hypoxic ischaemic encephalopathy undergoing hypothermia as provided at the Dutch paediatric formulary are compared with some recommendations reported in literature⁸⁰

	Recommendations as published		Dutch paediatric formulary
	LD	MD	LD	MD
Phenobarbital	20–40 mg/kg	/	20–40 mg/kg	2.5–5 mg/kg in 1–2 doses/day
Morphine	50 µg/kg	5 µg/kg/hour	50–100 µg/kg over 60 min	3–20 µg/kg/hour
Midazolam	0.05–0.1 mg/kg	0.05–0.1 mg/kg/hour	0.05 mg/kg	0.05–0.1 mg/kg/hour maximum 24 hours
Lidocaine	>2.0–2.5 kg:2 mg/kg (10 min) <2.5–4.5 kg:2 mg/kg (10 min)	6 mg/kg/hour (3.5 hours) → 3 mg/kg/hour (12 hours) → 1.5 mg/kg/hour (12 hours) 7 mg/kg/hour (3.5 hours) → 3.5 mg/kg/hour (12 hours) → 1.75 mg/kg/hour (12 hours)	2 mg/kg (10 min)	4 mg/kg/hour (6 hours) → 2 mg/kg/hour (12 hours) → stop
Topiramate	15 mg/kg	5 mg/kg/day	Not yet validated	Not yet validated
Erythropoietin	/	1.000 U/kg every 24 hours (3×) then every 48 hours (2×)	Not yet validated	Not yet validated
Darbepoetin	/	10 mcg/kg every 7 days (2×)	Not yet validated	Not yet validated
Gentamicin	/	4–5 mg/kg every 36 hours (5×)	/	5 mg/kg every 36 hours
Amikacin	/	15 mg/kg every 36 hours	Not yet validated	Not yet validated

LD, loading dose; MD, maintenance dose.