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. 2020 Jun 15;10(6):e035420. doi: 10.1136/bmjopen-2019-035420

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Forest plot of the result of univariate analysis for lactate dehydrogenase (LDH) (combined by standardised mean difference (SMD)). The result of univariate analysis in four studies was pooled for meta-analysis and a total of 118 patients were included. LDH was significantly associated with all-cause mortality with an SMD of 0.48 (95% CI 0.11 to 0.84, p=0.01). There was no heterogeneity (χ²=0.66, p=0.88, I²=0%).