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. 2020 Jun 15;10(6):e035420. doi: 10.1136/bmjopen-2019-035420

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Forest plot of the result of univariate analysis for oxygen therapy before acute exacerbation. The result of univariate analysis in four studies was pooled for meta-analysis and a total of 160 patients were included. Oxygen therapy before acute exacerbation was significantly associated with all-cause mortality with an HR of 1.88 (95% CI 1.15 to 3.09, p=0.01). There was no heterogeneity (χ²=2.05, p=0.56, I²=0%).