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. 2020 Jun 10;7:99. doi: 10.3389/fcvm.2020.00099

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Copyright © 2020 Nix, Ishikawa, Meyns, Yasuda, Adriaenssens, Barth, Zayat, Leprince and Lebreton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of experimental setup. (A) Timeline and experimental setup: The chosen model consisted of three different phases. In the first phase following coronary occlusion, marked in red, the animals were left in unsupported ischemia for 60 min. After this period, mechanical support was started (t = 0) following randomization and the animals were supported for another 30 min of ischemia by the respective device before reperfusion was initiated by re-opening of the coronary balloon. The animals were supported until sacrifice after 2 h of support under reperfusion; (B) The standardized animal instrumentation is shown. Of note, cannulation for MCS was only performed after randomization, thus, right sided cannulation depended on the chosen system of support.