Effect in C57BL/6NTac mice of 9.25 Gy TBI and mitigator combinations on protein levels in plasma at days 4 and 7 postirradiation. Subgroups of mice were injected at 24 h with JP4–039 (20 mg/kg), baicalein (50 mg/kg), or both, at 48 h with necrostatin-1 (1.65 mg/kg) or JP4–039 (20 mg/kg), and baicalein (50 mg/kg) at 24 h followed by necrostatin-1 (1.65 mg/kg) at 72 h. On days 4 and 7, plasma was isolated and Luminex assay was performed for the expression of inflammatory proteins. Panels A–C: Expressions are shown for IFN-γ, IL-5 and IL-6 (n = 5 mice per time point), respectively. Results are mean ± SEM. *P < 0.05 compared to day 0; #P < 0.05 compared to 9.25 Gy irradiation on same day.