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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Radiat Res. 2020 Mar 5;193(5):435–450. doi: 10.1667/RR15486.1

FIG. 9.

FIG. 9.

Effect of 9.25 Gy TBI and mitigator combinations on protein levels in lung at days 4 and 7. C57BL/6NTac female mice received 9.25 Gy TBI. Subgroups were injected at 24 h postirradiation with JP4–039 (20 mg/ kg), baicalein (50 mg/kg) or both JP4–039 (20 mg/kg) and baicalein (50 mg/kg). At 48 h after TBI a subgroup was injected with necrostatin-1 (1.65 mg/kg). Another subgroup was injected at 24 h after TBI with JP4–039 (20 mg/kg) and baicalein (50 mg/kg) followed at 72 h after TBI by an injection of necrostatin-1 (1.65 mg.kg). On day 4 and 7 the lungs were analyzed using Luminex assay for expression of inflammatory proteins. Panels A–C: Results are shown for IL-12 (p70), MCP-1 and VEGF (n = 5 mice per time point), respectively. Results are mean ± SEM. *P < 0.05 compared to day 0; #P < 0.05 compared to 9.25 Gy irradiation on same day.