Figure 5.

Effects of adenovirus-mediated overexpression of proximal tubule-specific, mitochondria-targeting mito-ECFP/Ang II in the kidney on systolic blood pressure and 24 h urinary Na⁺ excretion in conscious wild-type (WT), PT-Agtr1a^−/−, or PT-Nhe3^−/− mice. Panels A-C show that mitochondria-targeting expression of mito-ECFP/Ang II in the proximal tubules increased systolic blood pressure in WT, but not in PT-Agtr1a^−/− or PT-Nhe3^−/− mice. Conversely, mitochondria-targeting expression of mito-AT₂R/GFP in the proximal tubules of the kidney had no significant effect on blood pressure, but induced a significant natriuretic response in WT, PT-Agtr1a^−/−, or PT-Nhe3^−/− mice (D-F). **P<0.01 vs. basal or control wild-type mice. ⁺⁺P<0.01 vs. corresponding control or mito-ECFP/Ang II expressing WT mice.