Table 3. . Distribution of HLA-DRB1*07:01 and DQB1*02:02 alleles in childhood acute lymphoblastic leukemia patients in the replication cohort with and without systemic allergies.
HLA allele | Genotype | Allergies | OR (95% CI) | p-value | |
---|---|---|---|---|---|
Presence N (%)† | Absence N (%)† | ||||
DRB1*07:01 | 0 | 21 (60.0) | 155 (74.5) | 1 | |
DRB1*07:01- (DQB1*02:02)+ | 1 | 12 (34.3) | 38 (18.3) | 2.3 (1.1–5.2) | 0.003 |
DRB1*07:01- (DQB1*02:02)- | 1 | 2 (5.7) | 15 (7.2) | 1.0 (0.2–4.6) | 1.0 |
%: Frequency.
The association analysis in patients treated with Escherichia coli ASNase for DRB1*07:01 allele accompanied (+) or not (-) with DQB1*02:02. Presence of indicated HLA allele or haplotype is 1, and absence of DRB1*07:01 is 0. OR with 95% CI are presented along with p-values.
HLA: Human leukocyte antigen; N: Number; OR: Odds ratio.