. 2020 May 6;21(8):541–547. doi: 10.2217/pgs-2019-0195

Table 4. . Logistic regression model assessing the relationship between HLA-DRB107:01–DQB102:02 and the development of systemic allergies in the combined discovery and replication cohorts in the presence of nongenetic covariates.

	p-value	OR (95% CI)
HLA-DRB107:01–DQB102:02u	0.001	2.4 (1.4–4.2)
HLA-DRB107:01–DQB102:02m	0.001	2.6 (1.5–4.5)
NCI-risk groups	0.07	0.5 (0.3–1.1)
ALL phenotype	0.8	1.1 (0.4–3.3)
Protocols	0.2	0.8 (0.5–1.1)
Age	0.5	1.3 (0.6–3.2)
Sex	0.1	1.5 (0.9–2.5)
ASNase dose	0.7	1.1 (0.6–2.1)

HLA-DRB1*0701–DQB1*0202, presence (1) or absence (0) of both alleles; NCI-risk groups are standard (0) or high (1); ALL phenotype is B- (0) or T-cell leukemia (1); Age is ≥10 (1) or >10 years (0) and for sex, boys are 1 and girls 0. ASNase dose, fixed (0) or individualized (1) according to ASNase activity. Protocols include all four DFCI protocols (87-01, 91-01, 95-01 and 00-01), recoded from 1 to 4 starting from the most recent protocol.

ALL: Acute lymphoblastic leukemia; DFCI: Dana Farber Cancer Institute; HLA: Human leukocyte antigen; m: Multivariate analysis; NCI: National Cancer Institute; OR: Odds ratio; u: Univariate analyses.

Table 4. . Logistic regression model assessing the relationship between HLA-DRB1*07:01–DQB1*02:02 and the development of systemic allergies in the combined discovery and replication cohorts in the presence of nongenetic covariates.

Table 4. . Logistic regression model assessing the relationship between HLA-DRB107:01–DQB102:02 and the development of systemic allergies in the combined discovery and replication cohorts in the presence of nongenetic covariates.