Table 3.
Tissue optical properties, mean Photofrin concentration, light fluence, PDT dose and [ROS]rx at the surface of 12 pleural sites on 7 patients. The light fluence rate on surface is the same at 60Jcm−2 for all patients.
| Patient | Site | μa (cm−1) | μs’ (cm−1) | [Photofrin] (mg/kg) | Light fluence at surface (J/cm2) | PDT dose (μM J/cm2) | [ROS]rx (mM) |
|---|---|---|---|---|---|---|---|
| #20 | PM | 0.42 | 10.3 | 7.2 | 60 | 710.8 | 0.69 |
| #27 | ACW | 0.32 | 8.9 | 5.7 | 60 | 564.3 | 0.34 |
| #29 | PCW ACW |
0.65 0.38 |
13.2 9.6 |
9.8 6.0 |
60 60 |
965.3 594.0 |
1.17 0.46 |
| #35 | PM AS |
0.48 0.35 |
9.2 9.1 |
5.7 6.7 |
60 60 |
564.3 663.3 |
0.85 0.33 |
| #37 | PM Apex |
0.17 0.22 |
5.9 6.3 |
4.1 3.9 |
60 60 |
396.0 382.1 |
0.75 0.59 |
| #38 | PM PS |
0.23 0.62 |
6.8 12.3 |
4.4 10.4 |
60 60 |
435.6 1029.6 |
0.41 0.72 |
| #40 | PM AS |
0.25 0.35 |
10.2 11.2 |
4.1 6.7 |
60 60 |
403.9 659.3 |
0.31 0.41 |
| Average | 0.37 ± 0.15 | 9.4 ±2.2 | 6.2 ±2.1 | 60 | 614 ±202.6 | 0.59 ±0.25 |
PM: posterior mediastinum; ACW: anterior chest wall; PCW: posterior chest wall; AS: anterior sulcus; PS: posterior sulcus.
1mg/kg Photofrin =1.65μM Photofrin.