Table.
Patients' characteristics
| Characteristic | Healthy (n = 6) | mPAD (n = 6) | sPAD (n =5) |
|---|---|---|---|
| Age, years | 56.8 (54-62) | 73.8 (72-76) | 69 (68-82) |
| Male sex | 2 (33.3) | 4 (66.7) | 4 (80) |
| Clinical measurements at baseline | |||
| Creatinine concentration, mg/dL | 0.84 (0.16) | 1.14 (0.16) | 1.00 (.30) |
| ABI | – | 0.71 (0.45-0.80) | 0.74 (0.57-0.79) |
| Rutherford stage | – | 2.5 (2-3) | 4 (3-5) |
| Medical history | |||
| Coronary artery disease | 0 | 1 (16.7) | 1 (20) |
| Hypertension | 0 | 6 (100.0) | 5 (100) |
| Hyperlipidemia | 0 | 6 (100.0) | 5 (100) |
| Diabetes | 0 | 2 (33.3) | 4 (80) |
| Tobacco use | |||
| Never | 4 (66.7) | 0 (0.0) | 1 (20) |
| Current | 0 | 1 (16.7) | 1 (20) |
| Pack years smoked | 30 | 50 | |
| Former | 2 (33.3) | 5 (83.3) | 3 (60) |
| Pack-years smoked | 4 (3.88-12) | 35 (24-40) | 60 (35-60) |
| Takes daily aspirin | 0 | 6 (100.0) | 4 (80) |
| Takes daily statin | 0 | 5 (83.3) | 3 (60) |
ABI, Ankle-brachial index; mPAD, mild peripheral artery disease; sPAD, severe peripheral artery disease.
Categorical variables are presented as number (%). Continuous variables are presented as mean (standard deviation) or median (interquartile range).
Mild PAD is defined as ABI <0.9 with intermittent, nondisabling claudication, Rutherford stage 2 to 3. Severe PAD is defined as ABI <0.9 warranting lower extremity bypass grafting, Rutherford stage 3 to 5.