Table 3.

List of modules containing hot spots in the four examples, predicted hot spots, interactions where the residues participate as hot spots, partners that interact with the module, and references to experimentally verified hot spots located in the module (^a)[43]; ^b)[44]; ^c)[46]; ^d)[49]; ^e)[51]; ^f)[52]; ^g)[53]).

Module	Protein	Hot spots	Interaction	Module partners	Experimentally verified
A1	ubi3	R42, R72, L73, L74	ubp2	ubp2	R42a), R72a), L73 a), L74 a)
A2	ubi3	I44, F45	rad23	rad23	I44b), F45b)
A3	ubi3	F4	dsk2	ubp2,dsk2	F4c)
B1	cdc42	D63, Y64, R66, L67, L70	rdi1, lrg1	rdi1, lrg1	R66d)
B2	cdc42	T35	rdi1	rdi1	T35e)
C1	cob	W163, F168, R177, L262	isp	isp	G167f),g), G252f),g)
D1	cmk2	R31, F39, D102	akr1	akr1	-