Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of IGF-1R Signaling. The IGF-1 peptide analog, JB1, competitively binds to the IGF-1R. JB1 thus inhibits IGF-1 binding and prevents IGF-1R activation, ultimately blocking kinase signaling that would otherwise lead to cell survival and proliferation (repressed downstream effects indicated by the red “X”). Illustration based on Crudden, Girnita, A, and Girnita, L. [159].
