Fig. 1.

Schematic diagram showing procedures for studying the rescue effect by separating the rescue signals (represented by purple arrows) from the bystander signals (represented by brown arrows) through the preparation of the conditioned medium CM (represented in pink). The irradiated cells (blue) in IR dish sending out the bystander signals to bystander cells (red) are different from the irradiated cells (green) receiving the rescue signals. The experiments included three dishes, namely, the IR dish, CM dish and recipient dish.