Figure 2. Concurrent and opposite changes in lifespan account for the full wdr-5 mutant lifespan extension.

(A) Lifespan of early-, mid-, and late-gen wild-type (yellow, tangerine, and burnt orange, respectively) and wdr-5 mutant populations (lavender, purple, and plum, respectively) descended from animals recovered from a thaw. Data are also shown separated into wild-type (A’) and wdr-5 mutant populations (A’’). Percentage difference in median lifespan between early- and late-gen is indicated above arrow. p<0.05, **p<0.01, and ****p<0.0001 using log-rank test. Median lifespan and statistics are presented in supplementary file 1. Additional replicates are included in supplementary file 3.

Figure 2—figure supplement 1. Lifespan does not differ between populations descended from the same outcross.

Lifespan comparison of early-gen wild-type animals from a thaw (gold) to early-gen wild-type (gray) and wdr-5 mutant (purple) populations, both derived from outcrossing late-gen wdr-5 mutants and maintaining the population as heterozygotes for five generations. *p<0.05 between both wild-type populations using log-rank test. Median lifespan, statistics, and additional replicates are presented in supplementary file 3.