Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Strain, strain background (Mus musculus)	ShhCre/+	Liu et al., 2010	Jackson Lab	stock #: 005622
Strain, strain background (Mus musculus)	Atoh1-CreER+	Chow et al., 2006	MMRRC	stock #: 029581-UNC
Strain, strain background (Mus musculus)	vGlut3-iCreER/+	Li et al., 2018	Available upon request from Liu Lab	Please contact (zhiyongliu@ion.ac.cn)
Strain, strain background (Mus musculus)	Scrt2-P2A-tdTomato/+	It is a knockin mouse line where tdTomato can reflect Scrt2 mRNA expression pattern	Jackson Lab	stock #: 034390 (will be deposited soon)
Strain, strain background (Mus musculus)	Celf4-3xHA-P2A-iCreER-T2A-EGFP/+	It is a knockin mouse line where HA is tagged at Celf4 protein c terminus. In addition, iCreER and EGFP are controlled by Celf4 promoter/enhancer	Jackson Lab	stock #: 034391 (will be deposited soon)
RNA extraction kit	PicoPure RNA Isolation Kit	Thermo Scientific	Cat#: KIT0204	Extracting RNA from isolated cells
cDNA generation kit	Ovation RNA-Seq V2	Tecan Genomics	Cat#:7102–32	Converting RNA to cDNA
Library construction kit	Ovation Rapid DR Multiplex System	Tecan Genomics	Cat#: 0319–32	Generating sequencing library with eight samples multiplexing
Digestion enzyme	Protease	Sigma	Cat#: P5147	Digesting inner ear tissues