Table 5. Cohort 2—Summary of true-immunizations: mosquito bites, gland scores and duration of immunizations.

	Cohort 2
	All		Protected		Non-Protected
Number of Subjects	10		9		1
	Median	Range	Median	Range	Actual4
Total all bites1	1136	976–1333	1186	976–1333	1158
Total infected bites1	1026	839–1131	1022	839–1131	1038
Median bites per immunization1	220	77–270	221	77–251	218
Bites 1st immunization2	227	194–249	225	194–249	242
Bites 5th immunization2	77	41–96	76	41–96	86
Bites 2nd-4th immunization2	221	191–3271	218	192–266	237
Duration immunizations (days)	119	119–119	119	119–119	119
Interval before CHMI (days)	23	22–24	22	22–24	24
Gland score3 during immun.	3.6	2.9–3.9	3.6	2.9–3.9	3.7
Gland score 1st immun.	3.4	2.9–3.6	3.4	2.9–3.6	3.5
Gland score 5th immun.	3.7	3.5–3.9	3.7	3.5–3.9	3.7
Gland score 2nd-4th immun.	3.6	3.4–3.9	3.6	3.3–3.9	3.8
Gland score CHMI	3.5	3.0–3.8	3.4	3.0–3.8	3.6

The median and range of the immunizations are shown of all subjects in Cohort 2 who underwent CHMI. Since only one subject was non-protected, it was not possible to reliably do a statistical comparison.

¹Median of the numbers of bites at each immunization.

²Median of the numbers of bites for each subject at the first, fifth, and second-fourth immunizations.

³Gland score: as defined in Methods, salivary infection rates were defined as gland scores: 1–10 sporozoites = gland score 1; 11–100 sporozoites = gland score 2; 101–1,000 sporozoites = gland score 3; and > 1,000 = gland score 4. Median gland scores during immunization are the medians of median gland scores for each subject; ranges are values for each subject at each immunization.

⁴Median gland scores during 1^st immunization and 5^th immunizations and CHMI are the medians of gland scores for each subject; ranges are values for each subject at that immunization or CHMI.

⁵Actual values for one non-protected subject.