Table 6. Cohorts 1 and 2—Comparison of key parameters of true-immunizations.
Cohort 1 | Cohort 2 | ||||
---|---|---|---|---|---|
Number of Subjects | 11 | 10 | p | ||
Median | Range | Median | Range | ||
Total all bites | 1323 | 1111–1574 | 1136 | 976–1333 | 0.004 |
% mosquitoes infected | 80 | 70–87 | 88 | 83–93 | 0.001 |
Total infected bites | 1007 | 810–1235 | 1026 | 839–1131 | 0.65 |
Median bites per immun. | 210 | 175–239 | 220 | 77–270 | 0.4 |
Bites 1st immun. | 175 | 148–264 | 227 | 194–249 | 0.005 |
Bites 5th immun. | 239 | 186–272 | 77 | 41–96 | 0.0001 |
Bites 2nd-4th immun. | 210 | 175–210 | 221 | 191–3271 | 0.2 |
Duration immun. (days) | 119 | 119–119 | 119 | 119–119 | 1 |
Interval before CHMI (days) | 22 | 22–24 | 23 | 22–24 | 1 |
Gland score during immun. | 3.2 | 2.7–3.7 | 3.6 | 2.9–3.9 | 0.02 |
Gland score 1st immun. | 3.3 | 3.1–3.6 | 3.4 | 2.9–3.6 | 0.75 |
Gland score 5th immun. | 3.2 | 3.0–3.4 | 3.7 | 3.5–3.9 | 0.0001 |
Gland score 2nd-4th immun. | 3.2 | 2.7–3.7 | 3.6 | 3.4–3.9 | 0.0001 |
Gland score CHMI | 3.6 | 2.8–3.8 | 3.5 | 3.0–3.8 | 0.65 |
Summaries (mean, range) of immunizations in Cohorts 1 and 2 were compared using the Mann Whitney U test, where significance is p = ≤0.05.