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. 2020 Jun 5;16(6):e1008799. doi: 10.1371/journal.pgen.1008799

Fig 2. Activation of DNA damage response at telomeres in BRM-depleted cells.

Fig 2

(A) Condensation of telomere chromatin was determined by micrococcal nuclease assay. (B) IF-FISH detection of γH2AX foci in control and BRM-depleted VA13 cells. (C) Quantification of (B). Data represent the mean ± SEM of three independent experiments (n ≥ 100 cells), *P < 0.05. (D) IF-FISH detection of γH2AX foci in control and BRM-depleted HeLa cells. (E) Quantification of (D). Data represent the mean ± SEM of three independent experiments (n ≥ 100 cells), **P < 0.01, ***P < 0.001. (F) Western blot showing ATM activation in BRM-depleted VA13 cells. (G) Western blot showing ATM activation in BRM-depleted HeLa cells.