Table 5b: Tornado diagram*: VKA under PST versus dabigatran.
| Variable Name | Variable Description | Variable lowest bound | Variable highest bound | Lowest cost value | Highest costs value | SpreadƬ | Risk%¥ | Cum Risk% |
|---|---|---|---|---|---|---|---|---|
| cDabi | Drug costs of dabigatran per year in € | 958,21 | 1437,32 | 472,61 | 951,72 | 479,11 | 0,85 | 0,85 |
| pDepr | Period of depreciation | 3,00 | 10,00 | 622,65 | 779,30 | 156,65 | 0,09 | 0,94 |
| cCoatrain | Costs of training when using Coaguchek in € | 84,00 | 150,00 | 668,81 | 734,81 | 66,00 | 0,02 | 0,96 |
| cCoastrip | Costs of one CoaguChek test strips per in € | 2,29 | 3,43 | 679,68 | 744,77 | 65,09 | 0,02 | 0,97 |
| cCoasyst | Costs of CoaguChek INR device in € | 537,08 | 805,62 | 685,31 | 739,02 | 53,71 | 0,01 | 0,98 |
| noMajorBL_Dabi | No. of major bleedings per patient at risk and year underdDabigatran | 0,03 | 0,04 | 695,38 | 728,95 | 33,57 | 0,00 | 0,99 |
| noMajorBL_War_Dabi | Mo. of major bleedings per warfarin patient at risk and year in the dabigatran trial | 0,03 | 0,04 | 698,31 | 726,03 | 27,72 | 0,00 | 0,99 |
| cMarcu | Costs of phenprocoumon per year in € | 53,42 | 80,14 | 698,81 | 725,53 | 26,72 | 0,00 | 0,99 |
| noIS_War_Dabi | No. of ischemic strokes per warfarin patient at risk and year in the dabigatran trial | 0,01 | 0,01 | 699,81 | 724,53 | 24,72 | 0,00 | 1,00 |
| noIS_Dabi | No. of ischemic strokes per patient at risk and year under dabigatran | 0,01 | 0,01 | 700,29 | 724,05 | 23,75 | 0,00 | 1,00 |
| noHS_War_Dabi | No. of hemorrhagic strokes per warfarin patient at risk and year in the dabigatran trial | 0,00 | 0,01 | 705,24 | 719,09 | 13,85 | 0,00 | 1,00 |
| noHS_Dabi | No. of hemorrhagic strokes per patient at risk and year under dabigatran | 0,00 | 0,00 | 707,78 | 716,55 | 8,77 | 0,00 | 1,00 |
| cMajorBL | Costs of major bleeding per event in € | 3051,51 | 4577,27 | 708,69 | 715,64 | 6,95 | 0,00 | 1,00 |
| cHStroke | Costs of hemorrhagic stroke per event in € | 4384,42 | 6576,62 | 709,97 | 714,36 | 4,39 | 0,00 | 1,00 |
| cCoalanc | Costs of one lancet required for CoaguChek testing in € | 0,14 | 0,22 | 710,12 | 714,22 | 4,10 | 0,00 | 1,00 |
| cIStroke | Costs of ischemic stroke per event in € | 3595,02 | 5938,54 | 710,68 | 714,20 | 3,53 | 0,00 | 1,00 |
| cCoalab | Costs of laboratory controls by physician for self-managing patients per year in € | 2,88 | 4,32 | 711,45 | 712,89 | 1,44 | 0,00 | 1,00 |
| cPausch | Costs of care by settled physician per year in € | 90,72 | 136,08 | 712,17 | 712,17 | 0,00 | 0,00 | 1,00 |
*One-way sensitivity analyses of all model variables arranged in order, with the variable with the biggest impact at the top and the variable with the smallest impact at the bottom
¥ Risk%: This is a measure of how much of the total uncertainty is represented by the respective variable. The risk % values sum to 1.0 across all the variables.
Ƭ Highest cost value minus lowest cost value