Table 5c: Tornado diagram*: VKA under PST versus edoxaban.
| Variable Name | Variable Description | Variable lowest bound | Variable highest bound | Lowest cost value | Highest costs value | SpreadƬ | Risk%¥ | Cum Risk% |
|---|---|---|---|---|---|---|---|---|
| cEdox | Drug costs of edoxaban per year in € | 870.79 | 1306.18 | 385.69 | 821.08 | 435.39 | 0.828 | 0.83 |
| pDepr | Period of depreciation | 3.00 | 10.00 | 513.87 | 670.51 | 156.65 | 0.107 | 0.94 |
| cCoatrain | Costs of training when using Coaguchek in € | 84.00 | 150.00 | 560.02 | 626.02 | 66.00 | 0.019 | 0.95 |
| cCoastrip | Costs of one CoaguChek test strip in € | 2.29 | 3.43 | 570.89 | 635.98 | 65.09 | 0.019 | 0.97 |
| cCoasyst | Costs of CoaguChek INR device in € | 537.08 | 805.62 | 576.52 | 630.23 | 53.71 | 0.013 | 0.99 |
| noMajorBL_Edox | No. of major bleedings per patient at risk and year under edoxaban | 0.02 | 0.03 | 588.88 | 617.87 | 28.99 | 0.004 | 0.99 |
| noIS_Edox | No. of ischemic strokes per patient at risk and year under edoxaban | 0.01 | 0.01 | 587.05 | 614.76 | 27.71 | 0.003 | 0.99 |
| cMarcu | Costs of phenprocoumon per year in € | 53.42 | 80.14 | 590.02 | 616.74 | 26.72 | 0.003 | 1.00 |
| noIS_War_Edox | No. of ischemic strokes per wafarin patient at risk and year under edoxaban | 0.01 | 0.02 | 591.81 | 614.94 | 23.13 | 0.002 | 1.00 |
| noHS_War_Edox | No. of hemorrhagic strokes per warfarin patient at risk and year in the edoxaban trial | 0.00 | 0.01 | 596.33 | 610.43 | 14.10 | 0.001 | 1.00 |
| noHS_Edox | No. of hemorrhagic strokes per patient at risk and year under edoxaban | 0.00 | 0.00 | 596.80 | 609.96 | 13.15 | 0.001 | 1.00 |
| cCoalanc | Costs of one lancet required for CoaguChek testing in € | 0.14 | 0.22 | 601.33 | 605.43 | 4.10 | 0.000 | 1.00 |
| noMajorBL_War_Edox | No. of cases of major bleedings per warfarin patient at risk and year in the edoxaban trial | 0.03 | 0.03 | 612.58 | 616.57 | 3.99 | 0.000 | 1.00 |
| cIStroke | Costs of ischemic stroke per event in € | 3595.02 | 5938.54 | 601.67 | 604.63 | 2.96 | 0.000 | 1.00 |
| cHStroke | Costs of hemorrhagic stroke per event in € | 4384.42 | 6576.62 | 602.09 | 604.67 | 2.59 | 0.000 | 1.00 |
| cCoalab | Costs of laboratory controls by physician for self-managing patients per year in € | 2.88 | 4.32 | 602.66 | 604.10 | 1.44 | 0.000 | 1.00 |
| cMajorBL | Costs of major bleeding per event in € | 3051.51 | 4577.27 | 603.31 | 603.44 | 0.13 | 0.000 | 1.00 |
| cPausch | Costs of care by settled physician per year in € | 90.72 | 136.08 | 603.38 | 603.38 | 0.00 | 0.000 | 1.00 |
*One-way sensitivity analyses of all model variables arranged in order, with the variable with the biggest impact at the top and the variable with the smallest impact at the bottom
¥ Risk%: This is a measure of how much of the total uncertainty is represented by the respective variable. The risk % values sum to 1.0 across all the variables.
Ƭ Highest cost value minus lowest cost value