Table 3.

Tornado diagram^* (rapid POC influenza testing versus the conventional clinical approach)

Variable Name	Variable Description	Variable Lowest Bound	Variable Highest Bound	Lowest Cost Value (€)	Highest Cost Value (€)	Spread (€)τ	Threshold Valueμ	Risk%¥	Cumulative Risk%
Sofia_spec	Combined specificity of Sofia testing	0.915	0.992	−123.940	16.894	140.83	0.924	0.895	0.895
Sofia_sens	Combined sensitivity of Sofia testing	0.592	0.915	−70.683	−34.645	36.037	-	0.059	0.954
Clin_spec	Probability of correctly excluding non-influenza	0.572	0.630	−62.625	−42.591	20.034	-	0.018	0.972
cOpp	Opportunity costs due to blocking twin bed	280.150	420.230	−62.158	−43.059	19.099	-	0.016	0.988
Clin_sens	Sensitivity of diagnosing influenza if present	0.654	0.767	−58.505	−47.211	11.294	-	0.006	0.994
cPCR_ext	Costs of PCR in external laboratory	30.000	65.000	−57.233	−49.188	8.045	-	0.003	0.997
cSofia	Costs of Sofia test consumables inclusive	9.600	14.400	−55.008	−50.208	4.800	-	0.001	0.998
Flu_prev	Prevalence of influenza	0.200	0.426	−53.833	−49.142	4.690	-	0.001	0.999
pNI	Probability of NI treatment in per cent	0.000	1.000	−52.608	−48.282	4.326	-	0.001	1
sec_flu	Secondary cases due to one unknown influenza case	0.154	0.256	−53.202	−52.081	1.121	-	0	1
cRev_day	Additional revenue per day due to NI	186.770	280.150	−53.092	−52.125	0.967	-	0	1
cPL_day	Costs of productivity loss per day	125.590	188.390	−53.052	−52.164	0.888	-	0	1
sick_days	Number of days of HCW out of work due to influenza	5.760	8.640	−53.052	−52.164	0.888	-	0	1
cAntivir_day	Costs of virustatics per day	9.890	14.830	−52.988	−52.226	0.762	-	0	1
Vacc_eff	Effectiveness of influenza vaccination	0.150	0.490	−52.608	−52.278	0.330	-	0	1
pVacc_HCW	Probability of HCW	0.328	0.492	−52.637	−52.579	0.058	-	0	1
pHosp	Probability that hospitalization is required	0.157	0.230	−52.608	−52.608	0	-	0	1

^*One-way sensitivity analyses of all model variables arranged in order, with the variable with the biggest impact at the top and the variable with the smallest impact at the bottom;

^¥Risk%: This is a measure of how much of the total uncertainty is represented by the respective variable. The Risk% values sum to 1.0 across all the variables;

^τHighest cost value minus lowest cost value;

^μIndicates the point at which absolute savings turn to expenditures.

HCW: health care workers.