Table A1. Demographics, Disease Characteristics, HCRU, and Medications for SCD Patients 16-18 Years of Age Based on the Number of Vaso-occlusive Crises.
| Overall 16-18-year old (N=1186) | 16-to-18-year-old | |||
| Number of Vaso-occlusive Crises | ||||
|
0
(n=716) |
1 (n=137) | 2+ (n=333) | ||
| Patients with SCD, n (%) | 60.4 | 11.6 | 28.1 | |
| Age, mean (SD) | 17.0 (0.8) | 17.1 (0.8) | 16.9 (0.8) | 17.0 (0.8) |
| Gender, n (%) | ||||
| Male | 423 (35.7) | 199 (27.8) | 65.0 (47.4) | 159 (47.7) |
| Female | 763 (64.3) | 517 (72.2) | 72 (52.6) | 174 (52.3) |
| Ethnicity, n (%) | ||||
| White | 32 (2.7) | 26 (3.6) | 2 (1.5) | 4 (1.2) |
| Black | 901 (76.0) | 587 (82.0) | 101 (73.7) | 213 (64.0) |
| Hispanic | 14 (1.2) | 12 (1.7) | 0 (0) | 2 (0.6) |
| Other | 233 (19.6) | 85 (11.9) | 34 (24.8) | 114 (34.2) |
| Missing/Unknown | 6 (0.5) | 6 (0.8) | 0 (0) | 0 (0) |
| Charlson Comorbidity Index, mean (SD) | 1.3 (0.7), n=369 | 1.3 (0.8), n=187 | 1.3 (0.5), n=41 | 1.4 (0.8), n=141 |
| VOC Episode, mean (SD) | 3.9 (4.2), n=470 | 0 (0), n=0 | 1.0 (0), n=137 | 5.1 (4.4), n=333 |
| SCD Complications, n (%) | ||||
| Acute | 206 (17.4) | 70 (9.8) | 22 (16.1) | 114 (34.2) |
| Chronic | 725 (61.1) | 379 (52.9) | 80 (58.4) | 266 (79.9) |
| Cerebrovascular Disease | 69 (5.8) | 45 (6.3) | 5 (3.6) | 19 (5.7) |
| Hepatic Disease | 76 (6.4) | 21 (2.9) | 11 (8.0) | 44 (13.2) |
| Pulmonary Disease | 369 (31.1) | 169 (23.6) | 37 (27.0) | 163 (48.9) |
| Renal Disease | 106 (8.9) | 55 (7.7) | 10 (7.3) | 41 (12.3) |
| Spleen Disease | 6 (0.5) | 0 (0) | 0 (0) | 6 (1.8) |
| Other | 576 (48.6) | 275 (38.4) | 60 (43.8) | 241 (72.4) |
| SCD-related HCRU, mean (SD) | ||||
| Length of Stay (Hospital) | 9.0 (14.4), n=544 | 4.2 (8.1), n=248 | 5.4 (10.1), n=41 | 14.3 (17.6), n=255 |
| Hospital Admissions | 2.0 (2.3), n=544 | 1.1 (0.4), n=248 | 1.3 (0.8), n=41 | 3.0 (3.0), n=255 |
| ER Visits | 3.4 (4.0), n=687 | 1.8 (1.1), n=283 | 1.9 (1.3), n=94 | 5.3 (5.3), n=310 |
| Office Visits | 5.0 (4.2), n=806 | 4.1 (4.0), n=357 | 4.7 (3.4), n=130 | 6.1 (4.4), n=319 |
| Other Outpatients Visits | 7.9 (11.0), n=831 | 5.6 (9.9), n=384 | 6.7 (7.7), n=128 | 11.1 (12.5), n=319 |
| SCD Managements, mean (SD) | ||||
| Blood transfusions | 8.4 (7.0), n=137 | 9.0 (7.3), n=50 | 8.1 (4.9), n=15 | 8.0 (7.1), n=72 |
| Pneumococcal vaccines | 1.1 (0.3), n=100 | 1.1 (0.3), n=30 | 1.1 (0.3), n=25 | 1.2 (0.4), n=45 |
| Meningococcal vaccines | 1.2 (0.5), n=227 | 1.2 (0.5), n=112 | 1.2 (0.5), n=30 | 1.2 (0.5), n=85 |
| Bone marrow transplants | 1.0 (0.0), n=2 | 1.0 (0.0), n=2 | 0.0 (0.0), n=0 | 0.0 (0.0), n=0 |
| Transcranial doppler ultrasonography | 1.2 (0.5), n=105 | 1.3 (0.7), n=28 | 1.1 (0.3), n=22 | 1.2 (0.5), n=55 |
| SCD Medications, mean (SD) | ||||
| Antibiotics | 2.7 (2.6), n=691 | 2.4 (2.2), n=387 | 2.9 (2.7), n=69 | 3.2 (3.0), n=235 |
| Antidepressants | 3.9 (4.1), n=137 | 3.0 (2.9), n=76 | 5.6 (3.5), n=10 | 4.9 (5.2), n=51 |
| Antimetabolite | 5.3 (3.2), n=272 | 5.9 (3.5), n=48 | 5.8 (3.2), n=51 | 5.0 (3.1), n=173 |
| Iron chelating therapy | 8.6 (10.0), n=70 | 10.2 (12.3), n=29 | 4.3 (2.7), n=9 | 8.3 (8.7), n=32 |
| NSAIDs | 2.9 (2.5), n=742 | 2.1 (1.9), n=370 | 2.7 (2.1), n=100 | 4.1 (2.9), n=272 |
| Opioids | 4.7 (5.9), n=672 | 2.0 (2.6), n=263 | 3.5 (3.2), n=101 | 7.4 (7.3), m=308 |
| Others | 4.3 (3.2), n=353 | 4.4 (3.4), n=86 | 4.7 (3.3), n=69 | 4.1 (3.0), n=198 |
ER, emergency room; HCRU, healthcare resource utilization; NSAID, Nonsteroidal anti-inflammatory drug; SCD, sickle cell disease; SD, standard deviation; VOC, vaso-occlusive.