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. 2020 May 28;6(1):e001242. doi: 10.1136/rmdopen-2020-001242

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Representation of time-to-outcome curves for the relationship between time to treatment initiation and the chance to achieve sDFR. (A) Shows a non-linear relationship between time of treatment onset and the outcome sDFR. There is a short time frame with a high chance of achieving the outcome (until the bend in the curve) and a lost opportunity thereafter. This would indicate a WOO. (B) Shows a linear relationship between time of treatment onset and the outcome sDFR, which is indicative of a more gradual decline in the chance of achieving the outcome. If this chance approaches zero with increasing symptom duration, this would also be indicative of a WOO.

sDFR, sustained drug-free remission; WOO, window of opportunity.