Appendix Table 2.
Week-level longitudinal maternal medication use by maternal treatment group, median 25(OH)D status and child EH and extent
| Treatment Group | Median 25(OH)D Status | Child EH Status | Child EH Extent Group | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | All | 400 IU (n=55) |
2000 IU (n=51) |
4000 IU (n=55) |
Deficient/Insufficient (n=58) |
Sufficient/Optimal (n=103) |
No EH (n=85) |
EH (n=60) |
No EH (n=85) |
EH=1 (n=23) |
EH>1 (n=32) |
|
| Reflux Meds | ||||||||||||
| Weeks 12–36 | 93 | 32 | 27 | 34 | 32 | 61 | 53 | 30 | 53 | 10 | 18 | |
| (57.8) | (58.2) | (52.9) | (61.8) | (55.2) | (59.2) | (62.4) | (50.0) | (62.4) | (43.5) | (56.3) | ||
| Week 12 | 22 | 7 | 7 | 8 | 9 | 13 | 12 | 7 | 12 | 3 | 4 | |
| (13.7) | (12.7) | (13.7) | (14.5) | (15.5) | (12.6) | (14.1) | (11.7) | (14.1) | (13.0) | (12.5) | ||
| Week 16 | 36 | 10 | 12 | 14 | 12 | 24 | 23 | 10 | 23 | 3 | 6 | |
| (22.4) | (18.2) | (23.5) | (25.5) | (20.7) | (23.3) | (27.1) | (16.7) | (27.1) | (13.0) | (18.8) | ||
| Week 20 | 33 | 14 | 8 | 11 | 7 | 26 | 21 | 11 | 21 | 4 | 6 | |
| (20.5) | (25.5) | (15.7) | (20.0) | (12.1) | (25.2) | (24.7) | (18.3) | (24.7) | (17.4) | (18.8) | ||
| Week 24 | 42 | 15 | 11 | 16 | 8 | 34 | 27 | 14 | 27 | 5 | 7 | |
| (26.1) | (27.3) | (21.6) | (29.1) | (13.8) | (33.0) | (31.8) | (23.3) | (31.8) | (21.7) | (21.9) | ||
| Week 28 | 49 | 19 | 11 | 19 | 14 | 35 | 29 | 16 | 29 | 5 | 10 | |
| (30.4) | (34.5) | (21.6) | (34.5) | (24.1) | (34.0) | (34.1) | (26.7) | (34.1) | (21.7) | (31.3) | ||
| Week 32 | 50 | 17 | 14 | 19 | 15 | 35 | 30 | 19 | 30 | 6 | 12 | |
| (31.1) | (30.9) | (27.5) | (34.5) | (25.9) | (34.0) | (35.3) | (31.7) | (35.3) | (26.1) | (37.5) | ||
| Week 36 | 55 | 17 | 19 | 19 | 15 | 40 | 33 | 19 | 33 | 7 | 12 | |
| (34.2) | (30.9) | (37.3) | (34.5) | (25.9) | (38.8) | (38.8) | (31.7) | (38.8) | (30.4) | (37.5) | ||
| Antacids | ||||||||||||
| Weeks 12–36 | 84 | 26 | 26 | 32 | 26 | 58 | 47 | 29 | 47 | 9 | 18 | |
| (52.2) | (47.3) | (51.0) | (58.2) | (44.8) | (56.3) | (55.3) | (48.3) | (55.3) | (39.1) | (56.3) | ||
| Week 12 | 16 | 4 | 6 | 6 | 7 | 9 | 10 | 4 | 10 | 1 | 3 | |
| (9.9) | (7.3) | (118) | (10.9) | (12.1) | (8.7) | (118) | (6.7) | (118) | (4.3) | (9.4) | ||
| Week 16 | 32 | 10 | 12 | 10 | 10 | 22 | 20 | 9 | 20 | 3 | 5 | |
| (19.9) | (18.2) | (23.5) | (18.2) | (17.2) | (21.4) | (23.5) | (15.0) | (23.5) | (13.0) | (15.6) | ||
| Week 20 | 27 | 11 | 7 | 9 | 7 | 20 | 18 | 8 | 18 | 3 | 4 | |
| (16.8) | (20.0) | (13.7) | (16.4) | (12.1) | (19.4) | (21.2) | (13.3) | (21.2) | (13.0) | (12.5) | ||
| Week 24 | 37 | 12 | 11 | 14 | 7 | 30 | 25 | 11 | 25 | 4 | 5 | |
| (23.0) | (21.8) | (21.6) | (25.5) | (12.1) | (29.1) | (29.4) | (18.3) | (29.4) | (17.4) | (15.6) | ||
| Week 28 | 40 | 13 | 9 | 18 | 10 | 30 | 24 | 13 | 24 | 4 | 8 | |
| (24.8) | (23.6) | (17.6) | (32.7) | (17.2) | (29.1) | (28.2) | (21.7) | (28.2) | (17.4) | (25.0) | ||
| Week 32 | 38 | 12 | 10 | 16 | 12 | 26 | 25 | 12 | 25 | 5 | 7 | |
| (23.6) | (21.8) | (19.6) | (29.1) | (20.7) | (25.2) | (29.4) | (20.0) | (29.4) | (21.7) | (21.9) | ||
| Week 36 | 49 | 14 | 17 | 18 | 13 | 36 | 31 | 15 | 31 | 6 | 9 | |
| (30.4) | (25.5) | (33.3) | (32.7) | (22.4) | (35.0) | (36.5) | (25.0) | (36.5) | (26.1) | (28.1) | ||
| H2 Blocker | ||||||||||||
| Weeks 12–36 | 13 | 4 | 4 | 5 | 3 | 10 | 7 | 5 | 7 | 1 | 4 | |
| (8.1) | (7.3) | (7.8) | (9.1) | (5.2) | (9.7) | (8.2) | (8.3) | (8.2) | (4.3) | (12.5) | ||
| Week 12 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | |
| (0.6) | (0.0) | (0.0) | (18) | (0.0) | (1.0) | (1.2) | (0.0) | (1.2) | (0.0) | (0.0) | ||
| Week 16 | 3 | 1 | 0 | 2 | 1 | 2 | 3 | 0 | 3 | 0 | 0 | |
| (19) | (18) | (0.0) | (3.6) | (1.7) | (1.9) | (3.5) | (0.0) | (3.5) | (0.0) | (0.0) | ||
| Week 20 | 4 | 2 | 1 | 1 | 0 | 4 | 2 | 2 | 2 | 1 | 1 | |
| (2.5) | (3.6) | (2.0) | (1.8) | (0.0) | (3.9) | (2.4) | (3.3) | (2.4) | (4.3) | (3.1) | ||
| Week 24 | 3 | 2 | 1 | 0 | 0 | 3 | 2 | 1 | 2 | 1 | 0 | |
| (19) | (3.6) | (2.0) | (0.0) | (0.0) | (2.9) | (2.4) | (1.7) | (2.4) | (4.3) | (0.0) | ||
| Week 28 | 7 | 4 | 2 | 1 | 2 | 5 | 4 | 2 | 4 | 1 | 1 | |
| (4.3) | (7.3) | (3.9) | (1.8) | (3.4) | (4.9) | (4.7) | (3.3) | (4.7) | (4.3) | (3.1) | ||
| Week 32 | 9 | 3 | 4 | 2 | 1 | 8 | 5 | 4 | 5 | 1 | 3 | |
| (5.6) | (5.5) | (7.8) | (3.6) | (1.7) | (7.8) | (5.9) | (6.7) | (5.9) | (4.3) | (9.4) | ||
| Week 36 | 7 | 2 | 4 | 1 | 0 | 7 | 5 | 2 | 5 | 1 | 1 | |
| (4.3) | (3.6) | (7.8) | (1.8) | (0.0) | (6.8) | (5.9) | (3.3) | (5.9) | (4.3) | (3.1) | ||
| Proton Pump Inhibitor | ||||||||||||
| Weeks 12–36 | 7 | 1 | 1 | 5 | 0 | 7 | 4 | 3 | 4 | 0 | 3 | |
| (4.3) | (18) | (2.0) | (9.1) | (0.0) | (6.8) | (4.7) | (5.0) | (4.7) | (0.0) | (9.4) | ||
| Week 12 | 2 | 0 | 0 | 2 | 0 | 2 | 1 | 1 | 1 | 0 | 1 | |
| (1.2) | (0.0) | (0.0) | (3.6) | (0.0) | (1.9) | (1.2) | (1.7) | (1.2) | (0.0) | (3.1) | ||
| Week 16 | 3 | 1 | 0 | 2 | 0 | 3 | 2 | 1 | 2 | 0 | 1 | |
| (19) | (18) | (0.0) | (3.6) | (0.0) | (2.9) | (2.4) | (1.7) | (2.4) | (0.0) | (3.1) | ||
| Week 20 | 3 | 1 | 1 | 1 | 0 | 3 | 2 | 1 | 2 | 0 | 1 | |
| (19) | (18) | (2.0) | (1.8) | (0.0) | (2.9) | (2.4) | (1.7) | (2.4) | (0.0) | (3.1) | ||
| Week 24 | 4 | 1 | 1 | 2 | 0 | 4 | 2 | 2 | 2 | 0 | 2 | |
| (2.5) | (18) | (2.0) | (3.6) | (0.0) | (3.9) | (2.4) | (3.3) | (2.4) | (0.0) | (6.3) | ||
| Week 28 | 6 | 1 | 1 | 4 | 0 | 6 | 3 | 3 | 3 | 0 | 3 | |
| (3.7) | (18) | (2.0) | (7.3) | (0.0) | (5.8) | (3.5) | (5.0) | (3.5) | (0.0) | (9.4) | ||
| Week 32 | 6 | 1 | 1 | 4 | 0 | 6 | 4 | 2 | 4 | 0 | 2 | |
| (3.7) | (18) | (2.0) | (7.3) | (0.0) | (5.8) | (4.7) | (3.3) | (4.7) | (0.0) | (6.3) | ||
| Week 36 | 5 | 1 | 1 | 3 | 0 | 5 | 3 | 2 | 3 | 0 | 2 | |
| (3.1) | (18) | (2.0) | (5.5) | (0.0) | (4.9) | (3.5) | (3.3) | (3.5) | (0.0) | (6.3) | ||
| Antibiotics | ||||||||||||
| Weeks 12–36 | 46 | 15 | 16 | 15 | 25 | 19 | 27 | 13 | 27 | 6 | 6 | |
| (28.6) | (27.3) | (31.4) | (27.3) | (43.1) | (18.4) | (31.8) | (21.7) | (31.8) | (26.1) | (18.8) | ||
| Week 12 | 16 | 4 | 6 | 6 | 12 | 4 | 8 | 4 | 8 | 1 | 3 | |
| (9.9) | (7.3) | (118) | (10.9) | (20.7) | (3.9) | (9.4) | (6.7) | (9.4) | (4.3) | (9.4) | ||
| Week 16 | 16 | 5 | 6 | 5 | 6 | 10 | 10 | 6 | 10 | 3 | 2 | |
| (9.9) | (9.1) | (118) | (9.1) | (10.3) | (9.7) | (11.8) | (10.0) | (11.8) | (13.0) | (6.3) | ||
| Week 20 | 4 | 2 | 1 | 1 | 3 | 1 | 3 | 13 | 0 | 0 | ||
| (2.5) | (3.6) | (2.0) | (1.8) | (5.2) | (1.0) | (3.5) | (1.7) | (3.5) | (0.0) | (0.0) | ||
| Week 24 | 5 | 3 | 1 | 1 | 2 | 3 | 3 | 2 | 3 | 1 | 1 | |
| (3.1) | (5.5) | (2.0) | (1.8) | (3.4) | (2.9) | (3.5) | (3.3) | (3.5) | (4.3) | (3.1) | ||
| Week 28 | 6 | 3 | 1 | 2 | 2 | 4 | 5 | 1 | 5 | 1 | 0 | |
| (3.7) | (5.5) | (2.0) | (3.6) | (3.4) | (3.9) | (5.9) | (1.7) | (5.9) | (4.3) | (0.0) | ||
| Week 32 | 6 | 4 | 1 | 1 | 6 | 0 | 5 | 1 | 5 | 0 | 0 | |
| (3.7) | (7.3) | (2.0) | (1.8) | (10.3) | (0.0) | (5.9) | (1.7) | (5.9) | (0.0) | (0.0) | ||
| Week 36 | 7 | 3 | 2 | 2 | 4 | 2 | 4 | 3 | 4 | 2 | 1 | |
| (4.3) | (5.5) | (3.9) | (3.6) | (6.9) | (2.9) | (4.7) | (5.0) | (4.7) | (8.7) | (3.1) | ||
| Antifungals | ||||||||||||
| Weeks 12–36 | 27 | 8 | 8 | 11 | 7 | 17 | 17 | 5 | 17 | 2 | 2 | |
| (16.8) | (14.5) | (15.7) | (20.0) | (12.1) | (16.5) | (20.0) | (8.3) | (20.0) | (8.7) | (6.3) | ||
| Week 12 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | |
| (0.6) | (0.0) | (2.0) | (0.0) | (0.0) | (1.0) | (0.0) | (1.7) | (0.0) | (0.0) | (3.1) | ||
| Week 16 | 5 | 1 | 0 | 4 | 3 | 2 | 2 | 2 | 2 | 0 | 1 | |
| (3.1) | (18) | (0.0) | (7.3) | (5.2) | (19) | (2.4) | (3.3) | (2.4) | (0.0) | (3.1) | ||
| Week 20 | 7 | 5 | 1 | 1 | 3 | 4 | 6 | 1 | 6 | 0 | 1 | |
| (4.3) | (9.1) | (2.0) | (18) | (5.2) | (3.9) | (7.1) | (1.7) | (7.1) | (0.0) | (3.1) | ||
| Week 24 | 6 | 1 | 2 | 3 | 2 | 4 | 5 | 1 | 5 | 0 | 0 | |
| (3.7) | (18) | (3.9) | (5.5) | (3.4) | (3.9) | (5.9) | (1.7) | (5.9) | (0.0) | (0.0) | ||
| Week 28 | 4 | 2 | 1 | 1 | 0 | 4 | 3 | 1 | 3 | 1 | 0 | |
| (2.5) | (3.6) | (2.0) | (18) | (0.0) | (3.9) | (3.5) | (1.7) | (3.5) | (4.3) | (0.0) | ||
| Week 32 | 6 | 3 | 2 | 1 | 2 | 4 | 5 | 1 | 5 | 1 | 0 | |
| (3.7) | (5.5) | (3.9) | (18) | (3.4) | (3.9) | (5.9) | (1.7) | (5.9) | (4.3) | (0.0) | ||
| Week 36 | 5 | 2 | 3 | 0 | 2 | 3 | 4 | 0 | 4 | 0 | 0 | |
| (3.1) | (3.6) | (5.9) | (0.0) | (3.4) | (2.9) | (4.7) | (0.0) | (4.7) | (0.0) | (0.0) | ||
| Fluconazole | ||||||||||||
| Weeks 12–36 | 13 | 5 | 3 | 5 | 4 | 5 | 8 | 1 | 8 | 0 | 1 | |
| (8.1) | (9.1) | (5.9) | (9.1) | (6.9) | (4.9) | (9.4) | (1.7) | (9.4) | (0.0) | (3.1) | ||
| Week 12 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | |
| (0.6) | (0.0) | (2.0) | (0.0) | (0.0) | (1.0) | (0.0) | (1.7) | (0.0) | (0.0) | (3.1) | ||
| Week 16 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | |
| (0.6) | (0.0) | (0.0) | (18) | (1.7) | (0.0) | (1.2) | (0.0) | (1.2) | (0.0) | (0.0) | ||
| Week 20 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | |
| (0.6) | (18) | (0.0) | (0.0) | (1.7) | (0.0) | (1.2) | (0.0) | (1.2) | (0.0) | (0.0) | ||
| Week 24 | 2 | 1 | 1 | 0 | 1 | 1 | 2 | 0 | 2 | 0 | 0 | |
| (1.2) | (18) | (2.0) | (0.0) | (1.7) | (1.0) | (2.4) | (0.0) | (2.4) | (0.0) | (0.0) | ||
| Week 28 | 2 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 2 | 0 | 0 | |
| (1.2) | (3.6) | (0.0) | (0.0) | (0.0) | (19) | (2.4) | (0.0) | (2.4) | (0.0) | (0.0) | ||
| Week 32 | 5 | 3 | 2 | 0 | 2 | 3 | 5 | 0 | 5 | 0 | 0 | |
| (3.1) | (5.5) | (3.9) | (0.0) | (3.4) | (2.9) | (5.9) | (0.0) | (5.9) | (0.0) | (0.0) | ||
| Week 36 | 2 | 2 | 0 | 0 | 1 | 1 | 2 | 0 | 2 | 0 | 0 | |
| (1.2) | (3.6) | (0.0) | (0.0) | (1.7) | (1.0) | (2.4) | (0.0) | (2.4) | (0.0) | (0.0) | ||