Table 2.
Effects of multiple variables on MACCE according to EuroSCORE Risk Score in Cox regression analysis.
| EuroSCORE ≤2 | EuroSCORE 3-5 | EuroSCORE ≥6 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | |
| Laboratory parameters | |||||||||
| NLR | 1.113 | 1.048-1.183 | <0.001* | 1.161 | 1.060-1.273 | 0.001* | 1.127 | 1.012-1.255 | 0.029* |
| WBC | 0.936 | 0.779-1.125 | 0.48 | 1.105 | 0.889-1.159 | 0.82 | 1.023 | 0.919-1.139 | 0.67 |
| Lymphocyte | 0.231 | 0.116-0.461 | <0.001* | 0.606 | 0.355-1.035 | 0.06 | 0.575 | 0.347-0.953 | 0.032* |
| Neutrophil | 1.143 | 0.916-1.426 | 0.23 | 1.175 | 1.000-1.380 | 0.05 | 1.070 | 0.955-1.198 | 0.24 |
| CrCL | 0.993 | 0.979-1.007 | 0.99 | 0.989 | 0.975-1.003 | 0.11 | 0.993 | 0.982-1.005 | 0.27 |
| Risk factors and medical history | |||||||||
| Age | 1.025 | 0.965-1.090 | 0.41 | 1.019 | 0.974-1.067 | 0.41 | 1.059 | 1.009-1.112 | 0.02* |
| History of MI | 2.016 | 0.740-5.494 | 0.17 | 1.426 | 0.666-3.057 | 0.36 | 1.213 | 0.616-2.387 | 0.57 |
| Family history of CAD | 0.635 | 0.234-1.722 | 0.37 | 0.594 | 0.240-1.469 | 0.26 | 0.236 | 0.57-0.984 | 0.047* |
| Hypertension | 5.241 | 1.773-15.490 | 0.003* | 1.899 | 0.877-4.115 | 0.1 | 1.532 | 0.772-3.042 | 0.22 |
| IDDM | 2.208 | 0.653-7.466 | 0.2 | 4.918 | 1.979-12.219 | 0.001* | 0.996 | 0.305-3.254 | 0.99 |
| Asymptomatic carotid stenosis | 0.048 | 0-90770.430 | 0.68 | 2.408 | 1.088-5.325 | 0.03* | 1.294 | 0.658-2.546 | 0.45 |
| PVD | 10.595 | 2.443-45.944 | 0.002* | 1.496 | 0.421-5.317 | 0.53 | 1.158 | 0.409-3.283 | 0.78 |
| Angiographic findings | |||||||||
| LMCA stenosis | 2.427 | 0.948-6.211 | 0.065 | 2.211 | 0.974-5.021 | 0.05 | 1.200 | 0.545-2.641 | 0.65 |
| Three-vessel disease | 1.862 | 0.687-5.049 | 0.22 | 1.168 | 0.515-2.653 | 0.71 | 1.898 | 0.829-4.349 | 0.13 |
| Perioperative data | |||||||||
| Perioperative IABP | - | - | - | 4.871 | 0.661-35.918 | 0.12 | 6.150 | 1.463-25.854 | 0.013* |
| Perioperative inotropic agent | 6.521 | 0.873-48.738 | 0.06 | 1.955 | 0.590-6.478 | 0.27 | 2.174 | 1.111-4.254 | 0.023* |
| Prolonged respiratory period | - | - | - | 5.369 | 1.260-22.883 | 0.023* | 2.010 | 0.477-8.467 | 0.34 |
| Perioperative renal failure | 0.046 | 0-244.968 | 0.48 | 3.861 | 1.800-8.282 | 0.001* | 2.679 | 1.361-5.270 | 0.004* |
| Cerebrovascular complication | 1.358 | 0.183-10.102 | 0.76 | 4.541 | 1.703-12.109 | 0.002* | 1.211 | 0.470-3.122 | 0.69 |
| Blood transfusion | 1.104 | 0.730-1.670 | 0.63 | 1.357 | 1.147-1.606 | <0.001* | 1.094 | 0.899-1.331 | 0.37 |
| Length of hospital stay | 1.125 | 0.697-1.816 | 0.63 | 1.075 | 0.914-1.264 | 0.38 | 1.111 | 1.007-1.224 | 0.035* |
*
Statistically significant difference. CAD=coronary artery disease; CI=confidence interval; CrCL=creatinine clearance; EuroSCORE=European System for Cardiac Operative Risk Evaluation; IABP=intra-aortic balloon pump; IDDM=insulin-dependent diabetes mellitus; LMCA=left main coronary artery; MACCE=major cardiac and cerebrovascular event; MI=myocardial infarction; NLR=neutrophil-lymphocyte ratio; OR=odds ratio; PVD=peripheral vascular disease; WBC=white blood cell count