Table 3.
Baseline demographic and clinical parameters according to NLR quartiles.
| Characteristics | Overall | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-value |
|---|---|---|---|---|---|---|
| n=751 | n=189 | n=188 | n=187 | n=187 | ||
| 0.17-1.83 | 1.84-2.47 | 2.48-3.23 | ≥ 3.24 | |||
| Laboratory parameters | ||||||
| NLR | 3.04±2.69 | 1.3 ± 0.34 | 2.05 ± 0.19 | 2.87 ± 0.2 | 5.94 ± 4.07 | <0.001* |
| WBC (×109/L) | 7.74±2.65 | 7.37±2.8 | 7.74±2.26 | 7.53±2.8 | 8.34±2.62 | <0.001* |
| CRP | 1.81±3.12 | 1.11±2.16 | 1.5±2.71 | 2.41±3.29 | 2.64±4.19 | 0.018* |
| Hg | 11.05±2.31 | 10.90±2.34 | 11.07±2.31 | 11.11±2.35 | 11.10±2.26 | 0.69 |
| CrCL | 101.98±35.63 | 93.62±35.27 | 101.48±33.72 | 106.19±35.76 | 106.84±36.47 | 0.002* |
| Demographics | ||||||
| Age (years) | 62.34±9.43 | 61.41±9.52 | 61.52±9.72 | 61.88±9.42 | 64.57±8.76 | 0.003* |
| Male | 577 (76.8) | 150 (79.4) | 136 (72.3) | 187 (80.7) | 140 (74.9) | 0.18 |
| Risk factors and medical history | ||||||
| EuroSCORE | 3.61±2.52 | 3.64±2.48 | 3.46±2.49 | 3.50±2.49 | 3.83±2.55 | 0.41 |
| CCS | 2.52±1.24 | 2.52±1.26 | 2.56±1.26 | 2.50±1.28 | 2.50±1.15 | 0.92 |
| USAP | 238 (31.7) | 62 (32.8) | 62 (33) | 63 (33.7) | 51 (27.3) | 0.51 |
| Obesity (BMI ≥30) | 225 (33.3) | 48 (25.4) | 63 (33.5) | 58 (31) | 56 (29.9) | 0.53 |
| Current smoker | 298 (39.7) | 90 (47.6) | 68 (36.2) | 88 (47.1) | 52 (27.8) | <0.001* |
| Hypertension | 371 (49.4) | 87 (46) | 90 (47.9) | 96 (51.3) | 98 (52.4) | 0.57 |
| Dyslipidaemia | 196 (26.1) | 51 (27) | 49 (26.1) | 46 (24.6) | 50 (26.7) | 0.95 |
| Family history of CAD | 206 (27.4) | 53 (28) | 55 (29.3) | 59 (31.6) | 39 (20.9) | 0.11 |
| IDDM | 54 (7.2) | 10 (5.3) | 9 (4.8) | 12 (6.4) | 23 (12.3) | 0.018* |
| COPD | 50 (6.7) | 10 (5.3) | 12 (6.4) | 9 (4.8) | 19 (10.2) | 0.15 |
| History of stroke | 28 (3.7) | 8 (4.2) | 7 (3.7) | 5 (2.7) | 8 (4.3) | 0.32 |
| PVD | 34 (4.5) | 12 (6.3) | 3 (1.6) | 6 (3.2) | 13 (7) | 0.027* |
| Asymptomatic carotid stenosis | 115 (15.3) | 35 (18.5) | 26 (13.8) | 24 (12.8) | 30 (16) | 0.42 |
| History of MI | 224 (29.8) | 59 (31.2) | 51 (27.1) | 61 (32.6) | 53 (28.3) | 0.63 |
| Estimated LVEF 30-49% | 191 (25.4) | 46 (24.3) | 51 (27.1) | 53 (28.3) | 41 (21.9) | 0.97 |
| Estimated LVEF <30% | 48 (6.4) | 13 (6.9) | 9 (4.8) | 9 (4.8) | 17 (9.1) | 0.27 |
| Mild mitral insufficiency | 79 (10.5) | 19 (10.1) | 17 (9) | 20 (10.6) | 23 (12.3) | 0.62 |
| Previous PCI | 73 (9.7) | 23 (12.2) | 15 (8) | 18 (9.6) | 20 (10.7) | 0.56 |
| Angiographic findings | ||||||
| Number of vessel disease | 2.61±0.6 | 2.6±0.59 | 2.53±0.68 | 2.64±0.55 | 2.67±0.58 | 0.18 |
| LMCA stenosis | 125 (16.6) | 28 (14.8) | 31 (16.5) | 30 (16) | 36 (19.3) | 0.7 |
| Three-vessel disease | 510 (67.9) | 125 (66.1) | 120 (63.8) | 128 (68.4) | 137 (73.3) | 0.24 |
Statistically significant difference. Values are presented as mean ± standard deviation or number (%), where appropriate. BMI=body mass index; CAD=coronary artery disease; COPD=chronic obstructive pulmonary disease; CrCL=creatinine clearance; CRP=C-reactive protein; CCS=Canadian Cardiovascular Society grading of angina; EuroSCORE=European System for Cardiac Operative Risk Evaluation; Hg=haemoglobin level; IDDM=insulin-dependent diabetes mellitus; LMCA=left main coronary artery; LVEF=left ventricular ejection fraction; MI=myocardial infarction; NLR=neutrophil-lymphocyte ratio; PCI=percutaneous coronary intervention; PVD=peripheral vascular disease; USAP=unstable angina pectoris; WBC=white blood cell count