Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 17;6(25):eaay5872. doi: 10.1126/sciadv.aay5872

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 7 — (A) Enrichment of the aberrant human TET2^MUT gene signature (241 genes with hyper-DMCs in their promoters) in mouse Tet2^−/− versus Tet2^+/+ GC B cells. (B) Enrichment of the aberrant mouse Tet2^−/− gene signature (614 genes with hyper-DMCs in their promoters) in human TET2^MUT versus TET2^WT DLBCL. (C) First and third columns of the heatmap represent the results of pathway enrichment analysis of 614 mouse and 241 human genes with hyper-DMCs in their promoters, respectively. FDR scores for these results were computed using hypergeometric test. Second and fourth columns represent the results of pathway enrichment analysis of the same gene sets, using GSEA in mouse Tet2^−/− versus Tet2^+/+ GC B cells and human TET2^MUT versus TET2^WT DLBCL, respectively. NES scores of all pathways in mouse and human are biased toward Tet2^−/−/TET2^WT.