FIGURE 4.

TAK1 silencing mitigated oxidative stress and dissipated ER stress in MI/R‐injured myocardium. A through L, The protein expression levels and optical density analysis of CHOP, cleaved caspase 12, ATF4, p‐eIF2α, p‐JNK, p‐PERK, p‐IRE1α, cleaved ATF‐6 and GRP‐78 in the myocardium (n = 6/group); (K) the concentration of malondialdehyde (MDA) and (L) the activity of superoxide dismutase (SOD) in myocardium (n = 6/group); (M) DHE staining and evaluate (N) the amount of ROS in cardiac tissue (n = 6/group), magnification, ×400; Data are shown as means ± SEM; *P < 0.05, between the indicated groups