Skip to main content
. 2020 May 7;24(12):6898–6907. doi: 10.1111/jcmm.15346

FIGURE 6.

FIGURE 6

CircWHSC1 targets the miR‐646‐NPM1 pathway to promote endometrial cancer development. The expression of miR‐646 increased significantly after miR‐646 was overexpressed in HEC‐1B overexpressing circWHSC1 cells (A). MiR‐646 reduced cell proliferation (B), migration (D) and invasion (E), and promotes apoptosis (C) in HEC‐1B overexpressing circWHSC1 cells. Overexpression of circWHSC1 increased the expression of NPM1, and vice versa, whereas miR‐646 overexpression reduces NPM1 expression in HEC‐1B overexpressing circWHSC1 cells (F). The results are representative of three separate experiments. *P < 0.05. NPM1, nucleophosmin 1m