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The mitochondrial unfolded protein response and cardioprotection. Schematic model of the mitochondrial unfolded protein response (UPRmt). Nicotinamide ribose, ischaemic preconditioning (IPC), oligomycin and doxycycline are therapeutic strategies that have been shown to reduce acute myocardial ischaemia/reperfusion injury (IRI) by enhancing the UPRmt, and Mfn2 has been shown to play a key role in the UPR
